Making a meaningful difference in the treatment of mental illness

We’re working to develop medicines that can make a meaningful difference in the lives of those living with psychiatric and neurological conditions, with an immediate focus on schizophrenia and behavioral symptoms associated with Alzheimer’s disease. Through deepening our understanding of these complex conditions, our goal is to develop medicines that can alleviate burdensome symptoms to help restore function to those living with serious mental illness.

Schizophrenia

Schizophrenia is a persistent and often disabling mental illness affecting how a person thinks, feels and behaves.1

Estimated to affect more than
21 million people worldwide
including 2.7 million people in the U.S.1

Comprised of three symptom domains:

Positive

  • Hallucinations
  • Delusions
  • Difficulty organizing and expressing thoughts

Negative

  • Difficulty enjoying life
  • Withdrawal from others
  • Lack of motivation

Cognitive

  • Memory impairment
  • Attention deficits
  • Poor concentration
  • Reduced executive function

Psychosis in Alzheimer’s disease

Dementia is a condition characterized by the loss of cognitive functioning, such as thinking, remembering, and reasoning, as well as behavioral abilities to an extent that interferes with the ability to perform everyday activities.8 Psychiatric symptoms, such as psychosis, are prevalent across all forms of dementia, with psychosis in Alzheimer’s disease as the most common subtype of dementia-related psychosis.

An estimated 8 million people are living with dementia in the U.S., with Alzheimer’s disease as the leading cause of dementia, accounting for an estimated 60-80% of all cases.8

Symptoms of psychosis may present in those living with dementia, including 30-50% of individuals with Alzheimer’s disease.9